Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.36 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10580662 | 0.88 | HTT (0.42) | CYP19A1PKMMAPTNPC1RAB9A | |
| SCHEMBL10581971 | 0.85 | GRIK1 (0.41) | CYP19A1PDE5AMAPTNPC1RAB9A | |
| SCHEMBL9663819 | 0.81 | CYP19A1 (0.42) | CYP19A1MAPTNPC1RAB9ASLC22A6 | |
| SCHEMBL9728182 | 0.81 | CYP19A1 (0.59) | CYP19A1PKML3MBTL1MAPTCYP3A4 | |
| SCHEMBL10579885 | 0.79 | MAPT (0.42) | PKML3MBTL1PDE5AMAPTMEN1 | |
| SCHEMBL9191692 | 0.78 | CYP19A1 (0.43) | CYP19A1PDE5AMAPTCYP3A4MEN1 | |
| SCHEMBL9198511 | 0.76 | CYP19A1 (0.39) | CYP19A1MAPTNPC1RAB9ACYP3A4 | |
| SCHEMBL9197258 | 0.76 | CYP1A2 (0.41) | CYP19A1CYP3A4GRIK1GRIA1GRIA2 | |
| SCHEMBL9728310 | 0.75 | CYP26A1 (0.45) | CYP19A1PKML3MBTL1MAPTNPC1 | |
| SCHEMBL9759953 | 0.75 | IDO1 (0.41) | L3MBTL1CYP3A4MEN1KMT2AWNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151421-A | Compounds for inhibition of metabolism of retinoids, for treatment for proliferation of epithelial cells and keratin disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5028606-A | Retinoid metabolism inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-02 | — | — | US | disclosed |