SCHEMBL9728667

SCHEMBL9728667

O=C(NC(=O)c1c(F)cc(F)cc1F)Nc1cc(Cl)c(C(F)(F)C(F)(F)F)cc1F

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
USP2 O75604 1/20 0.43
MAPT P10636 1/20 0.43
ALOX15 P16050 1/20 0.43
PYGL P06737 11/20 0.38
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
ATM Q13315 1/20 0.34
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9728939 0.93 KMT2A (0.46) KMT2AMEN1USP2MAPTALOX15
SCHEMBL9728328 0.90 MEN1 (0.49) KMT2AMEN1USP2MAPTALOX15
SCHEMBL9728428 0.89 KMT2A (0.61) KMT2AMEN1USP2MAPTALOX15
SCHEMBL9728416 0.82 KMT2A (0.59) KMT2AMEN1USP2MAPTALOX15
SCHEMBL9728568 0.81 KMT2A (0.38) KMT2AMEN1USP2MAPTALOX15
SCHEMBL9727936 0.81 KMT2A (0.40) KMT2AMEN1USP2MAPTALOX15
SCHEMBL10348390 0.80 KMT2A (0.51) KMT2AMEN1USP2MAPTALOX15
SCHEMBL9728249 0.79 KMT2A (0.64) KMT2AMEN1USP2MAPTALOX15
SCHEMBL9729542 0.78 RAB9A (0.41) KMT2AMEN1USP2MAPTALOX15
SCHEMBL9727748 0.78 MEN1 (0.52) KMT2AMEN1USP2MAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0246061-B1 A BENZOYLUREA DERIVATIVE AND ITS PRODUCTION AND USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-03-18 EP disclosed