Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.71 |
| ▸ | PIM1 | P11309 | 12/20 | 0.71 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.71 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728518 | 0.76 | NTRK1 (0.70) | NTRK1PIM1ACVR1CHEK1CDK2 | |
| SCHEMBL9728870 | 0.74 | NTRK1 (0.65) | NTRK1PIM1ACVR1CHEK1CDK2 | |
| SCHEMBL10474226 | 0.72 | EGLN2 (0.42) | NTRK1PIM1ACVR1NPC1L3MBTL1 | |
| SCHEMBL31277907 | 0.71 | NTRK1 (0.65) | NTRK1PIM1ACVR1CHEK1CDK2 | |
| SCHEMBL9728862 | 0.70 | NTRK1 (0.69) | NTRK1PIM1ACVR1CHEK1CDK2 | |
| SCHEMBL9868866 | 0.68 | LMNA (0.40) | NTRK1PIM1ACVR1L3MBTL1JAK2 | |
| SCHEMBL31278107 | 0.66 | NTRK1 (0.55) | NTRK1PIM1ACVR1CHEK1CDK2 | |
| SCHEMBL941347 | 0.66 | JAK2 (0.45) | JAK2 | |
| SCHEMBL9468475 | 0.64 | KDM4E (0.81) | NTRK1PIM1ACVR1CDK2NPC1 | |
| SCHEMBL15455367 | 0.63 | GRM2 (0.47) | NTRK1PIM1ACVR1CDK2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169850-A | Neurotropic or hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-12-08 | — | — | US | disclosed |
| US-5059691-A | Anxiolytic agents; hypotensive agents; nervous system disorders; cognition activators | AMERICAN CYANAMID COMPANY (US) | 1991-10-22 | — | — | US | disclosed |
| US-5013737-A | Hypotensive, anxiolytic, cognitive disorders | AMERICAN CYANAMID COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| US-4847256-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |