Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.51 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.50 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.49 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.47 |
| ▸ | ALDH1B1 | P30837 | 1/20 | 0.47 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245834 | 0.88 | MAP2K1 (0.62) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL972176 | 0.81 | ALDH1A1 (0.78) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL972746 | 0.74 | MAP2K1 (0.60) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5331232 | 0.74 | SLC26A3 (0.60) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL972168 | 0.72 | MAP2K1 (0.78) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5328894 | 0.71 | KDM4E (0.81) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3786044 | 0.71 | KDM4E (1.00) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5327916 | 0.71 | KDM4E (0.81) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL972629 | 0.71 | ALDH1A1 (0.57) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL970908 | 0.70 | MAP2K1 (0.59) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872142-B2 | Coumarin derivatives useful as TNFα inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-01-18 | — | — | US | disclosed |
| US-20100174076-A1 | COUMARIN DERIVATIVES USEFUL AS TNF ALPHA INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100174076-A1 | COUMARIN DERIVATIVES USEFUL AS TNF ALPHA INHIBITORS | TNF, NFKBIA, TNFRSF1A | KDM4E 4508/4885ALDH1A1 1402/4885SMN1; SMN2 4732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.