Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.37 |
| ▸ | ITGAL | P20701 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | ADK | P55263 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11172742 | 0.98 | PIK3CD (0.39) | PIK3CDPIK3CBPIK3CGFYNGPR84 | |
| Maleic Acid SCHEMBL11162454 | 0.85 | CCNC (0.44) | HASPINCCNT1CDK9 | |
| SCHEMBL2806310 | 0.82 | GPR84 (0.43) | GPR84NPC1TRPA1CA1CA2 | |
| SCHEMBL16241832 | 0.76 | HASPIN (0.51) | PIK3CDPIK3CBPIK3CGGPR84HASPIN | |
| SCHEMBL7493615 | 0.76 | HASPIN (0.51) | PIK3CDPIK3CBPIK3CGGPR84HASPIN | |
| Hydrochloric Acid SCHEMBL8560372 | 0.75 | HASPIN (0.50) | PIK3CDPIK3CBPIK3CGGPR84HASPIN | |
| SCHEMBL30071614 | 0.73 | AHR (0.61) | GPR84NPC1TRPA1CA1CA2 | |
| SCHEMBL1440181 | 0.73 | AHR (0.61) | GPR84NPC1TRPA1CA1CA2 | |
| SCHEMBL6151694 | 0.72 | ALDH1A1 (0.50) | FYNGPR84NPC1TRPA1CA1 | |
| Hydrochloric Acid SCHEMBL7763064 | 0.71 | AHR (0.58) | GPR84NPC1TRPA1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250179-A2 | BCD tricyclic ergoline part-structure analogues | ELI LILLY AND COMPANY (US) | 1987-12-23 | — | — | EP | claimed |
| EP-0013788-B1 | OCTAHYDRO-2H-PYRROLO(3,4-G)QUINOLINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1983-04-27 | — | — | EP | claimed |
| US-5134143-A | Dopamine Agonists | ELI LILLY AND COMPANY (US) | 1992-07-28 | — | — | US | disclosed |
| US-5134143-A | Dopamine Agonists | ELI LILLY AND COMPANY (US) | 1992-07-28 | — | — | US | disclosed |
| CN-1016872-B | BCD TRICYCLIC ERGOLINE PART-STRUCTURE ANALOGUSE | LILLY CO ELI (US) | 1992-06-03 | — | — | CN | disclosed |
| US-4977160-A | DOPAMINE AGONISTS; PARKINSON*S DISEASE | ELI LILLY AND COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| US-4977160-A | DOPAMINE AGONISTS; PARKINSON*S DISEASE | ELI LILLY AND COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| US-4826986-A | DOPAMINE AGONISTS | ELI LILLY AND COMPANY (US) | 1989-05-02 | — | — | US | disclosed |
| US-4826986-A | DOPAMINE AGONISTS | ELI LILLY AND COMPANY (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0250179-A2 | BCD tricyclic ergoline part-structure analogues | ELI LILLY AND COMPANY (US) | 1987-12-23 | — | — | EP | disclosed |
| EP-0250179-A2 | BCD tricyclic ergoline part-structure analogues | ELI LILLY AND COMPANY (US) | 1987-12-23 | — | — | EP | disclosed |
| EP-0142920-A2 | 6-Oxodecahydroquinolines and process for their preparation | ELI LILLY AND COMPANY (US) | 1985-05-29 | — | — | EP | disclosed |
| EP-0013788-B1 | OCTAHYDRO-2H-PYRROLO(3,4-G)QUINOLINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1983-04-27 | — | — | EP | disclosed |
| US-4311844-A | Octahydro-2H-pyrrolo[3,4,-g]quinolines | ELI LILLY AND COMPANY (US) | 1982-01-19 | — | — | US | disclosed |
| US-4282362-A | TREATING PARKINSON'S DISEASE, INHIBITORS OF PRE ACTIN SECRETION, DOPAMINE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1981-08-04 | — | — | US | disclosed |
| US-4235909-A | DOPAMINE ANTAGONISTS, IN THE TREATMENT OF PARKINSON'S DISEASE | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| EP-0013788-A1 | Octahydro-2H-pyrrolo(3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |