Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 13/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.38 |
| ▸ | ZDHHC20 | Q5W0Z9 | 2/20 | 0.37 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729154 | 0.92 | KCNH2 (0.41) | KCNH2 | |
| SCHEMBL17026408 | 0.83 | KCNH2 (0.53) | KCNH2DNM1 | |
| SCHEMBL20658202 | 0.83 | KCNH2 (0.53) | KCNH2DNM1 | |
| SCHEMBL5081835 | 0.79 | ZDHHC20 (0.49) | KCNH2DNM1ZDHHC20ZDHHC2 | |
| SCHEMBL4170086 | 0.79 | ZDHHC20 (0.49) | KCNH2DNM1ZDHHC20ZDHHC2 | |
| SCHEMBL16922398 | 0.73 | KCNH2 (0.47) | KCNH2DNM1 | |
| Water SCHEMBL27663616 | 0.73 | DNM1 (0.52) | KCNH2DNM1 | |
| SCHEMBL20658215 | 0.73 | KCNH2 (0.50) | KCNH2 | |
| Water SCHEMBL337260 | 0.72 | DNM1 (0.58) | KCNH2DNM1 | |
| Water SCHEMBL9628255 | 0.72 | DNM1 (0.58) | KCNH2DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162360-A | Treating hypercholesterolemia and atherosclerosis; ACAT acyl-coenzyme A:-cholesterol acyltransferase | WARNER-LAMBERT COMPANY (US) | 1992-11-10 | — | — | US | disclosed |