Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31544361 | 1.00 | ALOX5 (0.54) | ALOX5NR1H4PTGS1PTGS2MAOB | |
| SCHEMBL10310537 | 0.89 | PTGS1 (0.46) | ALOX5NR1H4PTGS1PTGS2MAOB | |
| SCHEMBL8627404 | 0.88 | MAOB (0.57) | ALOX5NR1H4PTGS1PTGS2MAOB | |
| SCHEMBL10088476 | 0.85 | PTGS1 (0.44) | ALOX5NR1H4PTGS1PTGS2MAOB | |
| SCHEMBL2328053 | 0.85 | ALOX5 (0.41) | ALOX5NR1H4PTGS1PTGS2MAOB | |
| SCHEMBL10088425 | 0.83 | CA2 (0.45) | ALOX5NR1H4PTGS1PTGS2MAOB | |
| SCHEMBL10088438 | 0.80 | PARP10 (0.43) | ALOX5NR1H4PTGS1PTGS2MAOB | |
| SCHEMBL2323839 | 0.78 | STS (0.39) | ALOX5NR1H4PTGS1PTGS2MAOB | |
| SCHEMBL10088453 | 0.78 | NPC1 (0.54) | ALOX5MAOBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14712977 | 0.77 | ALOX5 (0.50) | ALOX5NR1H4PTGS1PTGS2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155130-A | Lipoxygenase inhibitors | CIBA-GEIGY CORPORATION (US) | 1992-10-13 | — | — | US | disclosed |