Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 17/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729527 | 1.00 | ALOX5 (0.51) | ALOX5ALOX12PTGS1PTGS2MAOB | |
| SCHEMBL9729708 | 0.83 | ALOX5 (0.54) | ALOX5ALOX12PTGS1PTGS2MAOB | |
| Sulfurous Acid SCHEMBL9729885 | 0.80 | ALOX5 (0.52) | ALOX5ALOX12PTGS1PTGS2MAOB | |
| SCHEMBL9164541 | 0.76 | ALDH1A1 (0.40) | ALOX5ALDH1A1HPGD | |
| SCHEMBL9164535 | 0.76 | ALDH1A1 (0.40) | ALOX5ALDH1A1HPGD | |
| SCHEMBL9731620 | 0.76 | ALOX5 (0.56) | ALOX5ALOX12PTGS1PTGS2 | |
| SCHEMBL9162389 | 0.74 | HPGD (0.51) | ALDH1A1HPGDKDM4ENPC1GAA | |
| SCHEMBL9162399 | 0.74 | HPGD (0.51) | ALDH1A1HPGDKDM4ENPC1GAA | |
| SCHEMBL9729495 | 0.73 | ALOX5 (0.61) | ALOX5ALOX12PTGS1PTGS2 | |
| SCHEMBL9730986 | 0.73 | ALOX5 (0.64) | ALOX5ALOX12PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155130-A | Lipoxygenase inhibitors | CIBA-GEIGY CORPORATION (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0412939-A2 | Certain benzopyran and benzothiopyran derivatives | CIBA-GEIGY AG (CH) | 1991-02-13 | — | — | EP | disclosed |