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Sugi Predict / Compounds / Formamide

Formamide

Formamide

SCHEMBL9729689

CCCCCCOc1ccc2c(c1)C=C(CNO)CO2.NC=O

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 13/20 0.63
▸ MTNR1A P48039 3/20 0.53
▸ MTNR1B P49286 1/20 0.39
▸ ALOX12 P18054 1/20 0.39
▸ PTGS1 P23219 1/20 0.39
▸ PTGS2 P35354 1/20 0.39
▸ HTR2A P28223 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9730115 0.94 ALOX5 (0.64) ALOX5MTNR1AMTNR1BALOX12
Formamide SCHEMBL9729662 0.85 ALOX5 (0.64) ALOX5MTNR1AALOX12PTGS1PTGS2
SCHEMBL7199698 0.82 MTNR1A (0.72) ALOX5MTNR1AMTNR1BALOX12
Urea SCHEMBL9730233 0.82 MTNR1A (0.68) ALOX5MTNR1AALOX12PTGS1PTGS2
Formamide SCHEMBL9729701 0.81 ALOX5 (0.62) ALOX5MTNR1AALOX12PTGS1PTGS2
SCHEMBL7204127 0.80 MTNR1A (0.77) ALOX5MTNR1AMTNR1BALOX12
SCHEMBL7203574 0.80 ALOX5 (0.66) ALOX5MTNR1AMTNR1BALOX12PTGS1
SCHEMBL7198793 0.80 ALOX5 (0.66) ALOX5MTNR1AALOX12PTGS1PTGS2
Formamide SCHEMBL9729455 0.80 ALOX5 (0.60) ALOX5MTNR1AALOX12PTGS1PTGS2
Formamide SCHEMBL9729793 0.79 ALOX5 (0.64) ALOX5MTNR1AALOX12PTGS1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5155130-A Lipoxygenase inhibitors CIBA-GEIGY CORPORATION (US) 1992-10-13 — — US disclosed
EP-0412939-A2 Certain benzopyran and benzothiopyran derivatives CIBA-GEIGY AG (CH) 1991-02-13 — — EP disclosed