Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.61 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.61 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 9/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31124778 | 0.83 | EGFR (0.65) | CLK1CSNK1DCSNK1EDYRK1AEGFR | |
| SCHEMBL4985353 | 0.83 | EGFR (0.65) | CLK1CSNK1DCSNK1EDYRK1AEGFR | |
| SCHEMBL8874014 | 0.82 | EGFR (0.58) | CLK1CSNK1DCSNK1EDYRK1AEGFR | |
| SCHEMBL4036768 | 0.80 | CLK1 (0.57) | CLK1CSNK1DCSNK1EDYRK1AHASPIN | |
| SCHEMBL445516 | 0.80 | CLK1 (0.57) | CLK1CSNK1DCSNK1EDYRK1AHASPIN | |
| SCHEMBL88606 | 0.79 | EGFR (0.58) | CLK1CSNK1DCSNK1EDYRK1AEGFR | |
| SCHEMBL29409356 | 0.79 | EGFR (0.58) | CLK1CSNK1DCSNK1EDYRK1AEGFR | |
| SCHEMBL7235686 | 0.78 | CLK1 (0.54) | CLK1CSNK1DCSNK1EDYRK1A | |
| SCHEMBL4750534 | 0.78 | CLK1 (0.54) | CLK1CSNK1DCSNK1EDYRK1A | |
| SCHEMBL13156497 | 0.78 | CLK1 (0.55) | CLK1CSNK1DCSNK1EDYRK1AHASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134143-A | Dopamine Agonists | ELI LILLY AND COMPANY (US) | 1992-07-28 | — | — | US | disclosed |
| US-4977160-A | DOPAMINE AGONISTS; PARKINSON*S DISEASE | ELI LILLY AND COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| US-4826986-A | DOPAMINE AGONISTS | ELI LILLY AND COMPANY (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0250179-A2 | BCD tricyclic ergoline part-structure analogues | ELI LILLY AND COMPANY (US) | 1987-12-23 | — | — | EP | disclosed |