Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ESRRA | P11474 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3889158 | 0.85 | ERN1 (0.71) | ERN1TRIM24TYRTRIM33 | |
| SCHEMBL3887594 | 0.82 | ERN1 (0.62) | ERN1TRIM24TYRTRIM33MEN1 | |
| SCHEMBL332380 | 0.81 | MAPT (0.62) | ERN1MAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL6093640 | 0.80 | ERN1 (0.61) | ERN1TRIM24TYRTRIM33CA1 | |
| SCHEMBL11417093 | 0.80 | MAPT (0.61) | ERN1MAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL9048075 | 0.79 | ERN1 (0.59) | ERN1ALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL2535056 | 0.79 | ERN1 (0.60) | ERN1MAPTSMN1; SMN2 | |
| SCHEMBL12952823 | 0.78 | ERN1 (0.54) | ERN1TRIM24TYRTRIM33 | |
| SCHEMBL2161314 | 0.76 | ALDH1A1 (0.40) | ERN1MAPTHPGDALDH1A1NPC1 | |
| SCHEMBL13580798 | 0.75 | TRPV1 (0.44) | MAPTHPGDALDH1A1NPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155130-A | Lipoxygenase inhibitors | CIBA-GEIGY CORPORATION (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0412939-A2 | Certain benzopyran and benzothiopyran derivatives | CIBA-GEIGY AG (CH) | 1991-02-13 | — | — | EP | disclosed |