Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.53 |
| ▸ | GPR17 | Q13304 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9730824 | 0.92 | GRIN1 (0.64) | GRIN1GPR17FBP1CNR1MAPT | |
| SCHEMBL9731281 | 0.88 | GRIN1 (0.67) | GRIN1GPR17FBP1MAPTMEN1 | |
| SCHEMBL9731682 | 0.83 | GRIN1 (0.54) | GRIN1GPR17FBP1CNR1 | |
| SCHEMBL9731831 | 0.81 | GRIN1 (0.80) | GRIN1GPR17FBP1CNR1MAPT | |
| SCHEMBL9739526 | 0.74 | GRIN1 (0.77) | GRIN1GPR17FBP1CNR1MEN1 | |
| SCHEMBL9732016 | 0.74 | GRIN1 (0.60) | GRIN1GPR17FBP1MAPTKMT2A | |
| SCHEMBL9731514 | 0.72 | GRIN1 (0.68) | GRIN1GPR17FBP1POLB | |
| SCHEMBL9740602 | 0.69 | GRIN1 (1.00) | GRIN1GPR17FBP1MAPTMEN1 | |
| SCHEMBL9740348 | 0.69 | GRIN1 (0.81) | GRIN1GPR17FBP1 | |
| SCHEMBL9740502 | 0.67 | GRIN1 (0.66) | GRIN1GPR17FBP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992020649-A2 | SUBSTITUTED 2-CARBOXYINDOLES HAVING PHARMACEUTICAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1992-11-26 | — | — | WO | claimed |
| WO-1992020649-A2 | SUBSTITUTED 2-CARBOXYINDOLES HAVING PHARMACEUTICAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1992-11-26 | — | — | WO | disclosed |
| US-5145845-A | Substituted 2-carboxylindoles having pharmaceutical activity | WARNER-LAMBERT CO. (US) | 1992-09-08 | — | — | US | disclosed |