Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.58 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 2/20 | 0.55 |
| ▸ | PLG | P00747 | 2/20 | 0.55 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.55 |
| ▸ | KLK1 | P06870 | 2/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.55 |
| ▸ | PLAT | P00750 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8161115 | 0.89 | NPC1 (0.62) | PLAUDEGS1NPC1RAB9AKDM4E | |
| SCHEMBL5430957 | 0.86 | PLAU (0.59) | PLAUDEGS1NPC1RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL8700251 | 0.84 | PLAU (0.58) | PLAUDEGS1NPC1RAB9AKDM4E | |
| Guanidine SCHEMBL27709689 | 0.84 | PLAU (0.58) | PLAUDEGS1NPC1RAB9AKDM4E | |
| SCHEMBL6010047 | 0.84 | F12 (0.55) | PLAUDEGS1NPC1RAB9AF2 | |
| SCHEMBL8009175 | 0.83 | NPC1 (0.59) | PLAUDEGS1NPC1RAB9AKDM4E | |
| SCHEMBL5432538 | 0.81 | CES2 (0.57) | PLAUDEGS1NPC1RAB9AKDM4E | |
| SCHEMBL27373888 | 0.81 | NPC1 (0.58) | DEGS1NPC1RAB9AKDM4ECES2 | |
| SCHEMBL1149678 | 0.81 | NPC1 (0.62) | DEGS1NPC1RAB9AKDM4ECES2 | |
| Naphthalene SCHEMBL27966015 | 0.81 | ALDH1A1 (0.60) | NPC1RAB9AMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106843-A | Treatment of migraine, emesis, anxiety, gastrointestinal disorders, psychological disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0323077-B1 | HETEROCYCLIC COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-4983600-A | Antiemetics, antianxiety agents, gastrointestinal disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1991-01-08 | — | — | US | disclosed |
| EP-0323077-A1 | Heterocyclic compounds | JOHN WYETH & BROTHER LIMITED (GB) | 1989-07-05 | — | — | EP | disclosed |