Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736383 | 0.89 | KCNH2 (0.50) | CACNA1FCHRM2ACHEAGTR1DRD3 | |
| SCHEMBL9733158 | 0.88 | KCNH2 (0.49) | CACNA1FCHRM2ACHEAGTR1DRD3 | |
| SCHEMBL9753597 | 0.85 | NPC1 (0.46) | CACNA1FCHRM2ACHEAGTR1DRD3 | |
| SCHEMBL9732998 | 0.83 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL9737861 | 0.83 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL9736710 | 0.83 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL9736388 | 0.81 | CYSLTR1 (0.48) | CYSLTR2CYSLTR1PDE10AGPBAR1ALOX5 | |
| SCHEMBL9737655 | 0.78 | KCNH2 (0.59) | ACHEDRD3KCNH2CYSLTR2CYSLTR1 | |
| SCHEMBL7861253 | 0.75 | KCNH2 (0.78) | CACNA1FCHRM2ACHEAGTR1DRD3 | |
| SCHEMBL9386001 | 0.75 | KCNH2 (0.69) | CACNA1FCHRM2ACHEAGTR1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084463-A | Cardiovascular disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | claimed |
| US-5104892-A | N-heteroalkyl substitutes 1-aryloxy-2-propanolamine | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-14 | — | — | US | disclosed |
| US-5084463-A | Cardiovascular disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | disclosed |
| WO-1991009023-A1 | N-HETEROARALKYL-SUBSTITUTED 1-ARYLOXY-2-PROPANOLAMINE AND PROPYLAMINE DERIVATIVES POSSESSING CLASS III ANTIARRHYTHMIC ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-06-27 | — | — | WO | disclosed |