Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9737271 | 0.88 | MAPT (0.45) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9736902 | 0.86 | MAPT (0.45) | PDE10AHTR5A | |
| SCHEMBL9737655 | 0.82 | KCNH2 (0.59) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL9733233 | 0.81 | CACNA1F (0.50) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL7234281 | 0.77 | TSHR (0.64) | — | |
| SCHEMBL1694951 | 0.77 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL21066731 | 0.77 | GPBAR1 (0.48) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL24943586 | 0.76 | NCF1 (0.52) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL4870435 | 0.75 | CARM1 (0.51) | CYSLTR1CYSLTR2ALOX5PDE10A | |
| SCHEMBL9736957 | 0.75 | CYSLTR1 (0.50) | CYSLTR1CYSLTR2GPBAR1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084463-A | Cardiovascular disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | disclosed |
| WO-1991009023-A1 | N-HETEROARALKYL-SUBSTITUTED 1-ARYLOXY-2-PROPANOLAMINE AND PROPYLAMINE DERIVATIVES POSSESSING CLASS III ANTIARRHYTHMIC ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-06-27 | — | — | WO | disclosed |