Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6297319 | 0.84 | ALDH1A1 (0.41) | ALDH1A1HTTMAPTLMNATDP1 | |
| SCHEMBL66583 | 0.75 | MAPT (0.46) | ALDH1A1HTTMAPTLMNATDP1 | |
| SCHEMBL67179 | 0.75 | MAPT (0.46) | ALDH1A1HTTMAPTLMNATDP1 | |
| SCHEMBL69085 | 0.75 | MAPT (0.46) | ALDH1A1HTTMAPTLMNAMEN1 | |
| SCHEMBL5051522 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HTTMAPTLMNAPTPN1 | |
| SCHEMBL16316322 | 0.72 | MEN1 (0.44) | ALDH1A1HTTMAPTLMNATDP1 | |
| SCHEMBL4543292 | 0.72 | ALDH1A1 (0.64) | ALDH1A1HTTMAPTLMNATDP1 | |
| SCHEMBL15541597 | 0.71 | MEN1 (0.43) | ALDH1A1MAPTLMNATDP1TSHR | |
| SCHEMBL2073308 | 0.71 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNATDP1TSHR | |
| SCHEMBL2075313 | 0.71 | KDM4E (0.47) | ALDH1A1TDP1TSHRAPPMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104892-A | N-heteroalkyl substitutes 1-aryloxy-2-propanolamine | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-14 | — | — | US | disclosed |
| WO-1991009023-A1 | N-HETEROARALKYL-SUBSTITUTED 1-ARYLOXY-2-PROPANOLAMINE AND PROPYLAMINE DERIVATIVES POSSESSING CLASS III ANTIARRHYTHMIC ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-06-27 | — | — | WO | disclosed |