Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | PNMT | P11086 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9443650 | 0.70 | LMNA (0.35) | HTR2BLMNAMAPK1ALDH1A1POLB | |
| SCHEMBL9240188 | 0.68 | KDM1A (0.40) | OPRM1OPRD1OPRK1HTR2AHTR2C | |
| SCHEMBL29804038 | 0.68 | KDM1A (0.40) | OPRM1OPRD1OPRK1HTR2AHTR2C | |
| SCHEMBL29122626 | 0.68 | HTR2A (0.39) | OPRM1OPRD1OPRK1HTR2AHTR2C | |
| SCHEMBL9733795 | 0.68 | HTR2A (0.36) | OPRM1OPRD1OPRK1HTR2AHTR2C | |
| SCHEMBL9733062 | 0.67 | HTR2A (0.38) | OPRM1OPRD1OPRK1HTR2AHTR2C | |
| SCHEMBL9732996 | 0.66 | OPRM1 (0.44) | OPRM1OPRD1OPRK1HTR2AHTR2C | |
| SCHEMBL27795745 | 0.65 | HTR2A (0.36) | OPRM1OPRD1OPRK1HTR2AHTR2C | |
| SCHEMBL21654448 | 0.65 | HTR2A (0.42) | OPRM1OPRD1OPRK1HTR2AHTR2C | |
| SCHEMBL9006983 | 0.65 | BACE1 (0.37) | HTR2CLMNAKMT2ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |