Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
| ▸ | CA6 | P23280 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31530864 | 0.85 | NOTUM (0.45) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL7414405 | 0.74 | KCNH2 (0.39) | KMT2AMEN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL308869 | 0.71 | PTPN1 (0.59) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL9043612 | 0.71 | POLB (0.46) | KMT2APOLBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9203728 | 0.70 | NPC1 (0.46) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL9042425 | 0.69 | GAA (0.41) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL8431884 | 0.69 | PTPN1 (0.50) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL15319525 | 0.68 | PTPN1 (0.49) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL11066860 | 0.68 | NPC1 (0.47) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL20116495 | 0.68 | CA12 (0.66) | NPC1KMT2AMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132424-A | Anticholesterol, treatment of atherosclerosis | THE UPJOHN COMPANY (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0425541-A1 | PYRAZOLO-AZOLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1991-05-08 | — | — | EP | disclosed |
| WO-1990001031-A1 | PYRAZOLO-PYRROLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1990-02-08 | — | — | WO | disclosed |