Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.60 |
| ▸ | LTA4H | P09960 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31484892 | 0.77 | HRH3 (0.78) | HRH3LTA4HNPC1TP53RAB9A | |
| SCHEMBL28048548 | 0.77 | HRH3 (0.64) | HRH3LTA4HKDM4ETSHR | |
| SCHEMBL3007724 | 0.76 | MCHR1 (0.51) | HRH3LTA4HSMN1; SMN2ALDH1A1 | |
| SCHEMBL15952657 | 0.76 | KIT (0.54) | HRH3LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7811609 | 0.76 | NPC1 (0.78) | HRH3LTA4HNPC1TP53RAB9A | |
| SCHEMBL10205684 | 0.76 | MCHR1 (0.64) | — | |
| SCHEMBL1859820 | 0.75 | HRH3 (1.00) | HRH3LTA4H | |
| SCHEMBL1856560 | 0.75 | HRH3 (0.79) | HRH3LTA4HTSHR | |
| SCHEMBL11956908 | 0.75 | RAB9A (0.52) | HRH3LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1680607 | 0.75 | MAOB (0.59) | LTA4HRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114945-A | Spiropiperidine derivatives | GLAXO GROUP LIMITED (GB) | 1992-05-19 | — | — | US | disclosed |
| EP-0330461-A2 | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 1989-08-30 | — | — | EP | disclosed |