Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9711250 | 0.78 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1ACHE | |
| SCHEMBL9780297 | 0.75 | ALDH1A1 (0.43) | CYSLTR2CYSLTR1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL9780294 | 0.75 | ALDH1A1 (0.43) | CYSLTR2CYSLTR1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL20244667 | 0.74 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1ACHE | |
| SCHEMBL9780346 | 0.73 | FFAR1 (0.39) | CYSLTR2CYSLTR1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL10547785 | 0.72 | CYSLTR2 (0.53) | CYSLTR2CYSLTR1ALDH1A1L3MBTL1FFAR1 | |
| SCHEMBL9863050 | 0.71 | CYSLTR2 (0.36) | CYSLTR2CYSLTR1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL10892238 | 0.71 | ALDH1A1 (0.40) | ALDH1A1GAAL3MBTL1ACHE | |
| SCHEMBL8165295 | 0.71 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1ACHEMMP12MMP13 | |
| SCHEMBL8165300 | 0.71 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1ACHEMMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135940-A | Antiallegens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1992-08-04 | — | — | US | disclosed |
| EP-0252639-A1 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1988-01-13 | — | — | EP | disclosed |
| EP-0104885-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-06-04 | — | — | EP | disclosed |
| EP-0156233-A2 | Use of leukotriene antagonists for producing cytoprotective pharmaceutical compositions and process for producing cytoprotective pharmaceutical compositions | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | disclosed |
| EP-0104885-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-04 | — | — | EP | disclosed |