⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736075 | 1.00 | — | — | |
| SCHEMBL9735131 | 0.97 | ACE2 (0.38) | — | |
| SCHEMBL9735134 | 0.97 | ACE2 (0.38) | — | |
| SCHEMBL7618670 | 0.88 | MMP2 (0.44) | — | |
| SCHEMBL14262421 | 0.86 | GRIN2B (0.46) | — | |
| SCHEMBL3054791 | 0.86 | NTSR1 (0.40) | — | |
| SCHEMBL3046330 | 0.85 | — | — | |
| SCHEMBL7618677 | 0.84 | — | — | |
| SCHEMBL7525973 | 0.84 | MMP2 (0.43) | — | |
| SCHEMBL7525987 | 0.84 | MMP2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166136-A | SPIROLACTAM CONTAINING PEPTIDES | GLAXO GROUP LIMITED (GB) | 1992-11-24 | — | — | US | disclosed |
| EP-0360390-A1 | Spirolactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-03-28 | — | — | EP | disclosed |