Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TLR4 | O00206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1613761 | 0.75 | MAPT (0.65) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL9833333 | 0.74 | ALDH1A1 (0.49) | MAPTALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL14829199 | 0.74 | ALDH1A1 (0.69) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL9831077 | 0.72 | ALDH1A1 (0.47) | MAPTALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL9056076 | 0.72 | MAPT (0.50) | MAPTALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL3534676 | 0.72 | KMT2A (0.45) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL28545713 | 0.72 | MAPT (0.60) | MAPTALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL14452368 | 0.71 | ALDH1A1 (0.46) | ALDH1A1TSHRKMT2AMEN1HPGD | |
| SCHEMBL3286134 | 0.70 | POLB (0.43) | ALDH1A1TSHRKMT2AMEN1MAPK1 | |
| SCHEMBL10668540 | 0.70 | ALDH1A1 (0.42) | MAPTALDH1A1TSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132424-A | Anticholesterol, treatment of atherosclerosis | THE UPJOHN COMPANY (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0425541-A1 | PYRAZOLO-AZOLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1991-05-08 | — | — | EP | disclosed |
| WO-1990001031-A1 | PYRAZOLO-PYRROLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1990-02-08 | — | — | WO | disclosed |
| US-4739076-A | WATER SOLUBLE, FOR PEPTIDES AND PROTEINS | SOUTHWICK PHILIP L (US) | 1988-04-19 | — | — | US | disclosed |