Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054959 | 0.90 | MAPT (0.42) | MAPTALDH1A1CYP1A2TSHRCYP2C19 | |
| SCHEMBL9057016 | 0.82 | MAPT (0.43) | MAPTALDH1A1CYP1A2TSHRCYP2C19 | |
| SCHEMBL9053052 | 0.81 | L3MBTL1 (0.39) | MAPTALDH1A1CYP1A2TSHRCYP2C19 | |
| SCHEMBL9042425 | 0.80 | GAA (0.41) | MAPTALDH1A1CYP1A2TSHRMEN1 | |
| SCHEMBL1613761 | 0.73 | MAPT (0.65) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9734800 | 0.72 | MAPT (0.56) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL1832087 | 0.72 | ALDH1A1 (0.57) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL17386339 | 0.72 | ALDH1A1 (0.50) | MAPTALDH1A1CYP1A2TSHRCYP2C19 | |
| SCHEMBL19417331 | 0.70 | MAPT (0.52) | MAPTALDH1A1CYP1A2TSHRCYP2C19 | |
| SCHEMBL1419881 | 0.70 | CYP1A2 (0.55) | MAPTALDH1A1CYP1A2TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0553130-B1 | PYRROLIDINE DIONE DERIVATIVES | PFIZER (US) | 1996-01-03 | — | — | EP | claimed |
| EP-0553130-A1 | PYRROLIDINE DIONE DERIVATIVES. | PFIZER (US) | 1993-08-04 | — | — | EP | claimed |
| WO-1992006954-A2 | PYRROLIDINE DIONE DERIVATIVES | PFIZER INC. (US) | 1992-04-30 | — | — | WO | claimed |
| EP-0553130-B1 | PYRROLIDINE DIONE DERIVATIVES | PFIZER (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0553130-A1 | PYRROLIDINE DIONE DERIVATIVES. | PFIZER (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1992006954-A2 | PYRROLIDINE DIONE DERIVATIVES | PFIZER INC. (US) | 1992-04-30 | — | — | WO | disclosed |