Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL893008 | 0.82 | POLB (0.49) | POLBGAAHSD11B1NPSR1LMNA | |
| SCHEMBL14230530 | 0.82 | POLB (0.49) | POLBGAAHSD11B1NPSR1LMNA | |
| SCHEMBL17704768 | 0.72 | POLB (0.42) | POLBGAAHSD11B1PARP1HTT | |
| SCHEMBL892454 | 0.72 | MEN1 (0.47) | POLBGAAHSD11B1KMT2AMEN1 | |
| SCHEMBL1069501 | 0.68 | HSD11B1 (0.40) | POLBGAAHSD11B1PARP1HTT | |
| SCHEMBL4515274 | 0.67 | NPC1 (0.42) | POLBGAAHSD11B1NPSR1ALDH1A1 | |
| SCHEMBL9734800 | 0.66 | MAPT (0.56) | POLBGAAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9243589 | 0.66 | GRM5 (0.40) | POLBGAAHSD11B1GRM5 | |
| SCHEMBL5381512 | 0.65 | PARP2 (0.46) | PARP1PARP2 | |
| SCHEMBL8659553 | 0.64 | NOS3 (0.41) | POLBGAAHSD11B1PARP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132424-A | Anticholesterol, treatment of atherosclerosis | THE UPJOHN COMPANY (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0425541-A1 | PYRAZOLO-AZOLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1991-05-08 | — | — | EP | disclosed |
| WO-1990001031-A1 | PYRAZOLO-PYRROLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1990-02-08 | — | — | WO | disclosed |