Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 5/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085392 | 0.91 | HTR1A (0.35) | ABCC9HTR1AABCB1PDE4APDE4B | |
| SCHEMBL9735036 | 0.90 | HTR1A (0.34) | ABCC9HTR1AABCB1PDE4APDE4B | |
| SCHEMBL9194883 | 0.88 | PDE4A (0.36) | ABCC9HTR1AABCB1PDE4APDE4B | |
| Bimakalim SCHEMBL231904 | 0.86 | PDE4A (0.43) | ABCC9HTR1AABCB1PDE4APDE4B | |
| SCHEMBL8088666 | 0.83 | CASP3 (0.34) | ABCC9HTR1AABCB1PDE4APDE4B | |
| SCHEMBL9735833 | 0.81 | CYP3A4 (0.38) | ABCB1MAOB | |
| SCHEMBL8133760 | 0.81 | HTR1A (0.33) | ABCC9HTR1APDE4APDE4BPDE4C | |
| SCHEMBL8084380 | 0.79 | OPRD1 (0.39) | ABCC9HTR1APDE4APDE4BPDE4C | |
| SCHEMBL8175110 | 0.79 | OPRD1 (0.39) | ABCC9HTR1APDE4APDE4BPDE4C | |
| SCHEMBL8084291 | 0.78 | OPRD1 (0.39) | ABCC9HTR1APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |