Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.40 |
| ▸ | PDCD4 | Q53EL6 | 8/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.38 |
| ▸ | GLS2 | Q9UI32 | 2/20 | 0.35 |
| ▸ | PNLIP | P16233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735388 | 0.85 | PDCD4 (0.40) | TOP1PDCD4DAGLAGLS2 | |
| SCHEMBL7296014 | 0.81 | PDCD4 (0.47) | TOP1PDCD4DAGLA | |
| SCHEMBL9325205 | 0.73 | PDCD4 (0.41) | PDCD4DAGLAPNLIP | |
| SCHEMBL9670112 | 0.71 | PDCD4 (0.41) | PDCD4GLS2 | |
| SCHEMBL9734705 | 0.70 | DAGLA (0.37) | TOP1PDCD4DAGLA | |
| SCHEMBL9745250 | 0.70 | PDCD4 (0.41) | PDCD4DAGLA | |
| SCHEMBL9422969 | 0.70 | PDCD4 (0.42) | PDCD4DAGLA | |
| SCHEMBL9745763 | 0.69 | PDCD4 (0.38) | PDCD4DAGLA | |
| SCHEMBL8985089 | 0.69 | PDCD4 (0.40) | PDCD4 | |
| SCHEMBL9745768 | 0.69 | PDCD4 (0.37) | PDCD4DAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134128-A | Immunosuppressive and antiproliferative activity for psoriasis and calcium homeostasis | ALLERGAN, INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0295056-A1 | Anti-inflammatory furanones | ALLERGAN, INC (US) | 1988-12-14 | — | — | EP | disclosed |