Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735495 | 0.81 | NR1H4 (0.48) | TSHRLTB4RLTB4R2 | |
| SCHEMBL9417917 | 0.80 | NR1H4 (0.47) | TSHRLTB4RLTB4R2 | |
| SCHEMBL9417949 | 0.70 | PPARA (0.42) | TSHRPPARA | |
| SCHEMBL9417802 | 0.70 | CYSLTR2 (0.34) | TSHRCYSLTR2CYSLTR1ALBLTB4R | |
| SCHEMBL28811440 | 0.70 | ALB (0.50) | TSHRCYSLTR2CYSLTR1ALBLTB4R | |
| SCHEMBL9417830 | 0.69 | PPARA (0.50) | TSHRPPARA | |
| SCHEMBL9735250 | 0.68 | CNR2 (0.41) | CYSLTR2CYSLTR1 | |
| SCHEMBL9737478 | 0.67 | NR1H4 (0.40) | TSHRCYSLTR2CYSLTR1LTB4RLTB4R2 | |
| SCHEMBL9417832 | 0.66 | NR1H4 (0.49) | — | |
| SCHEMBL9417757 | 0.65 | LTB4R (0.53) | TSHRLTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098613-A | Aromatic ethers for treatment of mammals | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-4945099-A | LEUKOTRIENE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0276065-B1 | ANTI-INFLAMMATORY AGENTS | ELI LILLY AND COMPANY (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0276065-A1 | Anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1988-07-27 | — | — | EP | disclosed |