Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735827 | 1.00 | C5AR1 (0.47) | C5AR1SRD5A1SRD5A2HTR1AADRA1D | |
| SCHEMBL2077679 | 0.90 | SRD5A1 (0.49) | SRD5A1SRD5A2HTR1AGAASTAT3 | |
| SCHEMBL1777085 | 0.86 | SRD5A1 (0.60) | SRD5A1SRD5A2HTR1AADRA1DADRA1A | |
| SCHEMBL187757 | 0.86 | SRD5A1 (0.60) | SRD5A1SRD5A2HTR1AADRA1DADRA1A | |
| SCHEMBL14252834 | 0.82 | L3MBTL1 (0.44) | SRD5A1SRD5A2HTR1AADRA1DADRA1A | |
| SCHEMBL186995 | 0.82 | STAT3 (0.48) | SRD5A1SRD5A2HTR1AADRA1DADRA1A | |
| SCHEMBL17429741 | 0.81 | PDE3B (0.50) | MAPTTLR8MAPK1TLR7POLB | |
| Hexane SCHEMBL27537617 | 0.81 | ALOX5 (0.53) | SRD5A2MAPTAPPL3MBTL1NSD2 | |
| SCHEMBL15952312 | 0.80 | SRD5A1 (0.42) | SRD5A1SRD5A2STAT3HTTSMN1; SMN2 | |
| SCHEMBL7098328 | 0.79 | SRD5A1 (0.49) | SRD5A1SRD5A2HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5126125-A | Decreasing the melanin content in mammalian skin and hair using 5,6-dihydroxindole derivatives | YALE UNIVERSITY (US) | 1992-06-30 | — | — | US | claimed |
| US-5126125-A | Decreasing the melanin content in mammalian skin and hair using 5,6-dihydroxindole derivatives | YALE UNIVERSITY (US) | 1992-06-30 | — | — | US | disclosed |
| US-4956174-A | COSMETICS, TANNING, PIGMENTATION | L'OREAL (FR) | 1990-09-11 | — | — | US | disclosed |
| US-4822375-A | LIGHTFAST, WEATHER RESISTANT, NATURAL APPEARING HAIR DYES | L'OREAL (FR) | 1989-04-18 | — | — | US | disclosed |