Sugi Predict

Sugi Predict / Compounds / SCHEMBL186995

SCHEMBL186995

SCHEMBL186995

Cc1cc2[nH]ccc2cc1OCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 1/20 0.48
▸ HTT P42858 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ BRD4 O60885 2/20 0.47
▸ L3MBTL1 Q9Y468 2/20 0.46
▸ MAPT P10636 2/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ POLB P06746 1/20 0.44
▸ FFAR4 Q5NUL3 1/20 0.44
▸ NSD2 O96028 1/20 0.43
▸ ABL1 P00519 1/20 0.43
▸ PPARG P37231 1/20 0.43
▸ RIN1 Q13671 1/20 0.43
▸ NCOR2 Q9Y618 1/20 0.43
▸ SRD5A1 P18405 1/20 0.42
▸ SRD5A2 P31213 1/20 0.42
▸ BACE1 P56817 1/20 0.42
▸ ENPP2 Q13822 1/20 0.41
▸ MAPK14 Q16539 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2077679 0.88 SRD5A1 (0.49) STAT3HTTSMN1; SMN2BRD4L3MBTL1
SCHEMBL1777085 0.84 SRD5A1 (0.60) SMN1; SMN2MAPTSRD5A1SRD5A2MAPK14
SCHEMBL187757 0.84 SRD5A1 (0.60) SMN1; SMN2MAPTSRD5A1SRD5A2MAPK14
SCHEMBL13594242 0.84 NOTUM (0.43) HTTSMN1; SMN2HTR1AADRA1DADRA1A
SCHEMBL14252834 0.83 L3MBTL1 (0.44) STAT3HTTSMN1; SMN2BRD4L3MBTL1
SCHEMBL188066 0.82 L3MBTL1 (0.50) STAT3HTTSMN1; SMN2L3MBTL1POLB
SCHEMBL1997971 0.82 GPR84 (0.50) STAT3HTTSMN1; SMN2BRD4L3MBTL1
SCHEMBL18593225 0.82 SMN1; SMN2 (0.44) STAT3HTTSMN1; SMN2L3MBTL1MAPT
SCHEMBL9735827 0.82 C5AR1 (0.47) STAT3HTTSMN1; SMN2L3MBTL1MAPT
SCHEMBL1493949 0.82 ENPP2 (0.42) STAT3HTTSMN1; SMN2BRD4L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3340983-B1 ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS ACHILLION PHARMACEUTICALS INC (US) 2023-10-04 — — EP disclosed
US-20230012449-A1 COMPOUNDS FOR THE TREATMENT OF HIV GILEAD SCIENCES, INC. 2023-01-12 — — US disclosed
US-11034668-B2 Compounds for the treatment of HIV GILEAD SCIENCES, INC. (US) 2021-06-15 — — US disclosed
US-10370358-B2 Compounds for the treatment of HIV GILEAD SCIENCES, INC. (US) 2019-08-06 — — US disclosed
US-10370358-B2 Compounds for the treatment of HIV GILEAD SCIENCES, INC. (US) 2019-08-06 — — US disclosed
US-20180194746-A1 Compounds For the Treatment of HIV GILEAD SCIENCES, INC. 2018-07-12 — — US disclosed
US-20180194746-A1 Compounds For the Treatment of HIV GILEAD SCIENCES, INC. 2018-07-12 — — US disclosed
US-20180194746-A1 Compounds For the Treatment of HIV GILEAD SCIENCES, INC. 2018-07-12 — — US disclosed
US-9944619-B2 Compounds for the treatment of HIV GILEAD SCIENCES, INC. (US) 2018-04-17 — — US disclosed
US-9944619-B2 Compounds for the treatment of HIV GILEAD SCIENCES, INC. (US) 2018-04-17 — — US disclosed
US-20110230454-A1 (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES KISSEI PHARMACEUTICAL CO., LTD. (JP) 2011-09-22 — — US disclosed
US-20110230454-A1 (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES KISSEI PHARMACEUTICAL CO., LTD. (JP) 2011-09-22 — — US disclosed
US-20110230454-A1 (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES KISSEI PHARMACEUTICAL CO., LTD. (JP) 2011-09-22 — — US disclosed
US-8003647-B2 (Aza)indole derivative and use thereof for medical purposes KISSEI PHARMACEUTICAL CO., LTD. (JP) 2011-08-23 — — US disclosed
US-8003647-B2 (Aza)indole derivative and use thereof for medical purposes KISSEI PHARMACEUTICAL CO., LTD. (JP) 2011-08-23 — — US disclosed
US-8003647-B2 (Aza)indole derivative and use thereof for medical purposes KISSEI PHARMACEUTICAL CO., LTD. (JP) 2011-08-23 — — US disclosed
US-20100056521-A1 (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES KISSEI PHARMACEUTICAL CO., LTD. (JP) 2010-03-04 — — US disclosed
US-20100056521-A1 (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES KISSEI PHARMACEUTICAL CO., LTD. (JP) 2010-03-04 — — US disclosed
US-20100056521-A1 (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES KISSEI PHARMACEUTICAL CO., LTD. (JP) 2010-03-04 — — US disclosed
EP-2133332-A1 (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES Kissei Pharmaceutical Co., Ltd. (JP) 2009-12-16 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10370358-B2 Compounds for the treatment of HIV CCR5, NPC1, FURIN STAT3 1920/4885HTT 4049/4885SMN1; SMN2 3500/4885
US-20180194746-A1 Compounds For the Treatment of HIV CCR5, NPC1, FURIN STAT3 1920/4885HTT 4049/4885SMN1; SMN2 3500/4885
US-20100056521-A1 (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES XDH, DAO, TDO2 STAT3 3589/4885HTT 3002/4885SMN1; SMN2 4080/4885
US-11034668-B2 Compounds for the treatment of HIV CCR5, NPC1, FURIN STAT3 1920/4885HTT 4049/4885SMN1; SMN2 3500/4885
US-20230012449-A1 COMPOUNDS FOR THE TREATMENT OF HIV CCR5, NPC1, FURIN STAT3 1920/4885HTT 4049/4885SMN1; SMN2 3500/4885
US-20110230454-A1 (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES XDH, DAO, TDO2 STAT3 3589/4885HTT 3002/4885SMN1; SMN2 4080/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.