Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 3/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11399307 | 0.88 | HPGD (0.60) | HPGDRECQLCA1CA2KMT2A | |
| SCHEMBL9735668 | 0.85 | HPGD (0.63) | HPGDRECQLCA1CA2KMT2A | |
| SCHEMBL7101006 | 0.83 | MAPT (0.60) | HPGDRECQLCA1CA2KMT2A | |
| SCHEMBL13444627 | 0.83 | LMNA (0.61) | HPGDRECQLCA1CA2KMT2A | |
| SCHEMBL5025348 | 0.80 | LMNA (0.70) | HPGDRECQLCA1CA2KMT2A | |
| SCHEMBL11378981 | 0.80 | MAPT (0.57) | HPGDRECQLCA1CA2KMT2A | |
| SCHEMBL28593702 | 0.80 | HPGD (0.65) | HPGDRECQLCA1CA2KMT2A | |
| SCHEMBL9107929 | 0.80 | CA1 (0.59) | HPGDRECQLCA1CA2KMT2A | |
| SCHEMBL3083718 | 0.79 | HPGD (0.63) | HPGDRECQLCA1CA2KMT2A | |
| SCHEMBL9804183 | 0.79 | HPGD (0.63) | HPGDRECQLCA1CA2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112866-A | Sulfonylfluorides as intermediates, also useful in treatment of bone disorders, antisecretory, antiulcer | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0358438-A2 | Ethanesulfonamide derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4874771-A | ANTISECRETORY, ANTIULCER AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |
| US-4814455-A | CALCIUM BLOCKERS, ANTICOAGULANTS | BRISTOL-MYERS COMPANY (US) | 1989-03-21 | — | — | US | disclosed |