Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 11/20 | 0.51 |
| ▸ | DRD2 known ✓ | P14416 | 10/20 | 0.51 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.51 |
| ▸ | KCNH2 known ✓ | Q12809 | 6/20 | 0.49 |
| ▸ | HTR7 | P34969 | 6/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9735742 | 1.00 | HTR2A (0.51) | HTR2ADRD2HTR2CHTR7KCNH2 | |
| SCHEMBL9684515 | 0.93 | HTR2A (0.56) | HTR2ADRD2HTR2CHTR1A | |
| SCHEMBL9683889 | 0.83 | DRD2 (0.61) | HTR2ADRD2HTR2CHTR1A | |
| Fumaric Acid SCHEMBL1545969 | 0.81 | ACHE (0.61) | HTR2ADRD2HTR7KCNH2 | |
| Fumaric Acid SCHEMBL1545971 | 0.81 | ACHE (0.61) | HTR2ADRD2HTR7KCNH2 | |
| SCHEMBL9378325 | 0.81 | DRD2 (0.61) | HTR2ADRD2HTR2C | |
| Fumaric Acid SCHEMBL9735299 | 0.81 | HTR2A (0.73) | HTR2ADRD2HTR2C | |
| Fumaric Acid SCHEMBL9683252 | 0.81 | HTR2A (0.73) | HTR2ADRD2HTR2C | |
| Fumaric Acid SCHEMBL1545316 | 0.78 | ACHE (0.76) | HTR2ADRD2HTR7KCNH2 | |
| Fumaric Acid SCHEMBL1545314 | 0.78 | ACHE (0.76) | HTR2ADRD2HTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5100902-A | Dopamine and Serotonin Antagonists, Antipsychotic Agents | ADIR ET COMPAGNIE (FR) | 1992-03-31 | — | — | US | disclosed |