Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | VHL | P40337 | 1/20 | 0.36 |
| ▸ | ELOC | Q15369 | 1/20 | 0.36 |
| ▸ | ELOB | Q15370 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844695 | 0.81 | SIGMAR1 (0.39) | THRBTP53KDM4EALDH1A1LMNA | |
| SCHEMBL9259274 | 0.80 | KDM4E (0.39) | SRD5A1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL946353 | 0.80 | MEN1 (0.39) | SRD5A1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL9259549 | 0.77 | HTR2A (0.44) | HTR2AHTR2CDRD3KMT2A | |
| SCHEMBL9736283 | 0.76 | SRD5A1 (0.40) | SRD5A1THRBMAPTKDM4EALDH1A1 | |
| SCHEMBL9264795 | 0.76 | KDM4E (0.56) | HTR2AHTR2CSRD5A1MAPTKDM4E | |
| SCHEMBL30684298 | 0.72 | ALOX5 (0.34) | — | |
| SCHEMBL18850958 | 0.71 | HTR2A (0.47) | HTR2AHTR2C | |
| SCHEMBL20777902 | 0.69 | HTR2A (0.38) | HTR2AHTR2CDRD3THRBTP53 | |
| SCHEMBL17907930 | 0.69 | HTR2A (0.48) | HTR2AHTR2CVHLELOCELOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021678-A1 | LIPOXYGENASE INHIBITING PYRROLO [1,2a]INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |