Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | VHL | P40337 | 1/20 | 0.32 |
| ▸ | ELOC | Q15369 | 1/20 | 0.32 |
| ▸ | ELOB | Q15370 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907965 | 0.87 | HTR2A (0.48) | HTR2AHTR2CNOTUMKMT2ARXFP1 | |
| SCHEMBL17907932 | 0.81 | SIGMAR1 (0.41) | HTR2AHTR2CNOTUMRXFP1MAPT | |
| SCHEMBL13279280 | 0.81 | SIGMAR1 (0.42) | HTR2AHTR2CNOTUMKDM4EALDH1A1 | |
| SCHEMBL235219 | 0.78 | NOTUM (0.59) | HTR2AHTR2CNOTUM | |
| SCHEMBL17907920 | 0.77 | HTR2A (0.51) | HTR2AHTR2CKMT2AMAPTKDM4E | |
| SCHEMBL13279354 | 0.71 | NOTUM (0.39) | HTR2AHTR2CNOTUM | |
| SCHEMBL9735949 | 0.69 | HTR2A (0.45) | HTR2AHTR2CKMT2AVHLELOC | |
| SCHEMBL17907947 | 0.68 | ALDH1A1 (0.38) | NOTUMKMT2AALDH1A1CCR2 | |
| SCHEMBL20777902 | 0.68 | HTR2A (0.38) | HTR2AHTR2CKMT2ARXFP1 | |
| SCHEMBL17809478 | 0.68 | HTR2A (0.55) | HTR2AHTR2CMMP14ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |