Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL433287 | 0.88 | HDAC9 (0.50) | HDAC9HCAR2TDP1KDM1AMAOB | |
| Biphenyl SCHEMBL27506403 | 0.83 | HDAC9 (0.46) | HDAC9HCAR2TDP1KDM1AMAOB | |
| Trimethylammonium SCHEMBL27680853 | 0.81 | HDAC9 (0.45) | HDAC9HCAR2TDP1LMNAKDM1A | |
| SCHEMBL30219063 | 0.77 | AKR1C1 (0.48) | HDAC9HCAR2KDM1ATSHRAKR1C1 | |
| SCHEMBL687495 | 0.77 | AKR1C1 (0.48) | HDAC9HCAR2KDM1ATSHRAKR1C1 | |
| SCHEMBL27989169 | 0.75 | SIGMAR1 (0.45) | LMNAMAOB | |
| SCHEMBL17335394 | 0.75 | KDM1A (0.46) | HDAC9HCAR2TDP1KDM1AMAOB | |
| SCHEMBL7434294 | 0.74 | SMN1; SMN2 (0.48) | HDAC9LMNA | |
| SCHEMBL5204567 | 0.74 | HDAC9 (0.40) | HDAC9HCAR2TDP1LMNAKDM1A | |
| SCHEMBL31536279 | 0.73 | HDAC9 (0.41) | HDAC9HCAR2TDP1LMNAKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135940-A | Antiallegens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1992-08-04 | — | — | US | disclosed |
| EP-0252639-A1 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1988-01-13 | — | — | EP | disclosed |