Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.32 |
| ▸ | MMP1 | P03956 | 3/20 | 0.32 |
| ▸ | MMP2 | P08253 | 3/20 | 0.32 |
| ▸ | MMP3 | P08254 | 3/20 | 0.32 |
| ▸ | MMP7 | P09237 | 3/20 | 0.32 |
| ▸ | MMP9 | P14780 | 3/20 | 0.32 |
| ▸ | MMP8 | P22894 | 3/20 | 0.32 |
| ▸ | MMP13 | P45452 | 3/20 | 0.32 |
| ▸ | MMP14 | P50281 | 3/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735761 | 1.00 | GRIN2B (0.35) | GRIN2BGRIN2CNTSR1HSD11B1ADAM10 | |
| SCHEMBL9735100 | 1.00 | GRIN2B (0.35) | GRIN2BGRIN2CNTSR1HSD11B1ADAM10 | |
| SCHEMBL9736221 | 1.00 | GRIN2B (0.35) | GRIN2BGRIN2CNTSR1HSD11B1ADAM10 | |
| SCHEMBL9734966 | 0.88 | NTSR1 (0.37) | GRIN2BGRIN2CNTSR1HSD11B1ADAM10 | |
| SCHEMBL9734738 | 0.84 | — | — | |
| SCHEMBL9736075 | 0.84 | — | — | |
| SCHEMBL9735131 | 0.81 | ACE2 (0.38) | — | |
| SCHEMBL9735134 | 0.81 | ACE2 (0.38) | — | |
| SCHEMBL14219500 | 0.80 | NTSR1 (0.36) | GRIN2BGRIN2CNTSR1HSD11B1SLC6A2 | |
| SCHEMBL3040420 | 0.79 | NTSR1 (0.40) | GRIN2BGRIN2CNTSR1HSD11B1ADAM10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166136-A | SPIROLACTAM CONTAINING PEPTIDES | GLAXO GROUP LIMITED (GB) | 1992-11-24 | — | — | US | disclosed |
| EP-0360390-A1 | Spirolactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-03-28 | — | — | EP | disclosed |