Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA3 | P07451 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115495 | 0.97 | DNM1 (0.48) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL3281516 | 0.97 | DNM1 (0.48) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL29480607 | 0.97 | DNM1 (0.48) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL11240602 | 0.95 | DNM1 (0.50) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL10933147 | 0.95 | DNM1 (0.50) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL9169385 | 0.95 | DNM1 (0.43) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL2259453 | 0.87 | DNM1 (0.43) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL8744280 | 0.86 | DNM1 (0.38) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL115864 | 0.85 | DNM1 (0.62) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL14840324 | 0.84 | SLC6A5 (0.39) | DNM1TSHRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-54079203-A | — | — | None | — | — | JP | disclosed |
| US-5118346-A | Phosphonium or ammonium salts | CIBA-GEIGY CORPORATION (US) | 1992-06-02 | — | — | US | disclosed |
| JP-S5479203-A | TRIENE COMPOUNDS AND PREPARATION THEREOF | TAKASAGO CORP | 1979-06-25 | — | — | JP | disclosed |