Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735438 | 0.88 | HTR1A (0.40) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22997428 | 0.84 | RAB9A (0.42) | ALOX5NPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL29446213 | 0.84 | RAB9A (0.42) | ALOX5NPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL26759036 | 0.84 | RAB9A (0.42) | ALOX5NPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL29446212 | 0.84 | RAB9A (0.42) | ALOX5NPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL29653912 | 0.84 | RAB9A (0.42) | ALOX5NPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL29446214 | 0.84 | RAB9A (0.42) | ALOX5NPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL29446222 | 0.84 | RAB9A (0.42) | ALOX5NPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL29653996 | 0.84 | RAB9A (0.42) | ALOX5NPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL11394655 | 0.84 | ALOX5 (0.45) | ALOX5NPC1RAB9ASMN1; SMN2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |