SCHEMBL9737144

SCHEMBL9737144

FC(F)(F)C(F)(F)C(F)(F)n1cncn1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.40
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3844330 0.86 LMNA (0.42) CYP19A1LMNA
SCHEMBL14332945 0.64 LMNA (0.44) CYP19A1LMNA
SCHEMBL427342 0.59 CYP19A1 (0.41) CYP19A1LMNA
SCHEMBL20711975 0.59 LMNA (0.48) CYP19A1LMNA
SCHEMBL22513576 0.57 LMNA (0.46) CYP19A1LMNA
SCHEMBL1563373 0.57 HSP90AA1 (0.47) CYP19A1LMNA
Hydrochloric Acid SCHEMBL247629 0.57 LMNA (1.00) CYP19A1LMNA
SCHEMBL9895088 0.56 CYP19A1 (0.41) CYP19A1
SCHEMBL9895086 0.56 FDPS (0.33) CYP19A1LMNA
SCHEMBL6080325 0.55

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992004335-A2 RENAL-SELECTIVE BIPHENYLALKYL 1H-SUBSTITUTED-1,2,4-TRIAZOLE ANGIOTENSIN II ANTAGONISTS FOR TREATMENT OF HYPERTENSION G.D. SEARLE & CO. (US) 1992-03-19 WO disclosed