Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carfentanil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 14/20 | 0.96 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.96 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.96 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.74 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carfentanil SCHEMBL116222 | 0.98 | OPRM1 (1.00) | OPRM1OPRD1OPRK1CACNA1COPRL1 | |
| [11C]-Carfentanil SCHEMBL29374424 | 0.98 | OPRM1 (1.00) | OPRM1OPRD1OPRK1CACNA1COPRL1 | |
| Carfentanil SCHEMBL238456 | 0.97 | OPRM1 (0.98) | OPRM1OPRD1OPRK1CACNA1COPRL1 | |
| Carfentanil SCHEMBL4256090 | 0.97 | OPRM1 (0.98) | OPRM1OPRD1OPRK1CACNA1COPRL1 | |
| Oxalic Acid SCHEMBL11567142 | 0.93 | OPRM1 (0.83) | OPRM1OPRD1OPRK1CACNA1COPRL1 | |
| Carfentanil SCHEMBL4385304 | 0.92 | OPRM1 (0.89) | OPRM1OPRD1OPRK1CACNA1COPRL1 | |
| Carfentanil SCHEMBL16444962 | 0.92 | OPRM1 (0.89) | OPRM1OPRD1OPRK1CACNA1COPRL1 | |
| SCHEMBL11565358 | 0.92 | OPRM1 (0.88) | OPRM1OPRD1OPRK1CACNA1COPRL1 | |
| Oxalic Acid SCHEMBL6045561 | 0.92 | OPRM1 (0.83) | OPRM1OPRD1OPRK1CACNA1COPRL1 | |
| Hydrochloric Acid SCHEMBL11565447 | 0.91 | OPRM1 (0.86) | OPRM1OPRD1OPRK1CACNA1COPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106983-A | Process of making carfentanil and related analgesics | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1992-04-21 | — | — | US | claimed |
| US-11545353-B2 | Logical operations in mass spectrometry | PURDUE RESEARCH FOUNDATION (US) | 2023-01-03 | — | — | US | disclosed |
| US-20210375612-A1 | LOGICAL OPERATIONS IN MASS SPECTROMETRY | PURDUE RESEARCH FOUNDATION (US) | 2021-12-02 | — | — | US | disclosed |
| US-11127581-B2 | Logical operations in mass spectrometry | PURDUE RESEARCH FOUNDATION (US) | 2021-09-21 | — | — | US | disclosed |
| US-20210013023-A1 | LOGICAL OPERATIONS IN MASS SPECTROMETRY | PURDUE RESEARCH FOUNDATION | 2021-01-14 | — | — | US | disclosed |
| EP-3199523-A1 | THE NEW PROCESS FOR PRODUCING N-PHENYL-N-(4-PIPERIDINYL) AMIDE DERIVATIVES SUCH AS REMIFENTANIL AND CARFENTANIL | Bioka s. r.o. (SK) | 2017-08-02 | — | — | EP | disclosed |
| US-5106983-A | Process of making carfentanil and related analgesics | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1992-04-21 | — | — | US | disclosed |