SCHEMBL9738384

SCHEMBL9738384

CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@H](P(c2ccccc2)c2ccccc2)CN1S(C)(=O)=O

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TOP2A P11388 1/20 0.33
ECE1 P42892 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9737870 0.72
SCHEMBL9737536 0.72
SCHEMBL19898477 0.69 SMYD2 (0.36)
SCHEMBL16589448 0.66 POLB (0.42)
SCHEMBL6402255 0.65 MAPT (0.38) TOP2A
SCHEMBL29302010 0.65 CHRM2 (0.40) TOP2A
SCHEMBL19898593 0.65 CAPN1 (0.36)
SCHEMBL10851219 0.65 ALDH1A1 (0.31)
SCHEMBL19898623 0.64 SMYD2 (0.35)
SCHEMBL10850879 0.64 KMT2A (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0251164-B1 NEW CHIRAL PHOSPHINOPYRROLIDINE COMPOUNDS AND THEIR USE FOR ASYMETRIC SYNTHESIS OF OPTICALLY ACTIVE COMPOUNDS Achiwa, Kazuo (JP) 1992-12-16 EP disclosed
US-4879389-A HYDROGENATION CATALYSTS ACHIWA KAZUO (JP) 1989-11-07 US disclosed
EP-0251164-A2 New chiral phosphinopyrrolidine compounds and their use for asymetric synthesis of optically active compounds Achiwa, Kazuo (JP) 1988-01-07 EP disclosed