Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11695799 | 0.85 | UGT2B7 (0.39) | LMNAPTGS1HIF1AHSD17B10GSK3B | |
| SCHEMBL70197 | 0.85 | LMNA (0.35) | LMNAPTGS1TRPA1CACNA1CNPSR1 | |
| SCHEMBL11695720 | 0.80 | GSK3B (0.30) | GSK3B | |
| SCHEMBL11851143 | 0.79 | CYP1A2 (0.40) | NPSR1HTTGSK3BMEN1KMT2A | |
| SCHEMBL300006 | 0.79 | PTGS1 (0.41) | PTGS1HIF1AGSK3BPTGS2 | |
| SCHEMBL2629600 | 0.78 | MEN1 (0.37) | LMNANPSR1ALDH1A1MEN1KMT2A | |
| SCHEMBL9886765 | 0.78 | LMNA (0.39) | LMNAPTGS1TRPA1CACNA1CNPSR1 | |
| SCHEMBL11694928 | 0.78 | ADRB2 (0.41) | LMNAGSK3BADRB2 | |
| SCHEMBL11693561 | 0.75 | PDE4D (0.40) | HPGDHSD17B10GSK3BADRB2 | |
| SCHEMBL11201231 | 0.74 | MMP12 (0.38) | ALDH1A1GAAALOX12HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128339-A | Emphysema, rheumatoid arthritis, pancreatitis | STERLING WINTHROP INC. (US) | 1992-07-07 | — | — | US | disclosed |