Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | MERTK | Q12866 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE1A | P54750 | 2/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738442 | 0.86 | PDE4A (0.56) | ADORA2AADORA1RPS6KA3MAPK8MAPK9 | |
| SCHEMBL9738831 | 0.80 | FGFR1 (0.50) | AXLMERTKFLT3ADORA2AADORA1 | |
| SCHEMBL9738462 | 0.80 | AXL (0.65) | AXLMERTKFLT3ADORA2AADORA1 | |
| SCHEMBL9739221 | 0.79 | ALDH1A1 (0.46) | AXLMERTKFLT3ADORA2AADORA1 | |
| SCHEMBL9738479 | 0.79 | AXL (0.53) | AXLMERTKFLT3ADORA2AADORA1 | |
| SCHEMBL10442404 | 0.78 | ADORA2A (0.51) | ADORA2AADORA1MAPK8MAPK9MAPK10 | |
| SCHEMBL8826403 | 0.77 | CYP1A2 (0.41) | ADORA2AADORA1RPS6KA3MAPK8MAPK9 | |
| SCHEMBL9741179 | 0.77 | CCR4 (0.48) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL9738497 | 0.77 | AXL (0.51) | AXLMERTKFLT3ADORA2AADORA1 | |
| SCHEMBL9739236 | 0.73 | AXL (0.52) | AXLMERTKFLT3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110818-A | Antiepileptic agents | CIBA-GEIGY CORPORATION (US) | 1992-05-05 | — | — | US | disclosed |
| EP-0363320-A2 | Substituted 9H purine | CIBA-GEIGY AG (CH) | 1990-04-11 | — | — | EP | disclosed |