Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 4/20 | 0.41 |
| ▸ | PDE8A | O60658 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | MERTK | Q12866 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738484 | 0.84 | FGFR1 (0.49) | FGFR1FGFR4ADORA2AADORA1PDE8A | |
| SCHEMBL782938 | 0.81 | YTHDC1 (0.53) | FGFR1FGFR4ADORA2AMAPK1ACP1 | |
| SCHEMBL9739221 | 0.80 | ALDH1A1 (0.46) | ADORA2AADORA1TSHRMAPK1AXL | |
| SCHEMBL9738685 | 0.80 | AXL (0.47) | FGFR1FGFR4ADORA2AADORA1TSHR | |
| SCHEMBL1578361 | 0.79 | PDE8A (0.51) | ADORA2AADORA1PDE8AAXLMERTK | |
| SCHEMBL9739273 | 0.77 | ACP1 (0.49) | FGFR1FGFR4ADORA2ATSHRACP1 | |
| SCHEMBL3959823 | 0.77 | PDE8A (0.67) | ADORA2AADORA1PDE8A | |
| SCHEMBL23093469 | 0.75 | CYP1A2 (0.43) | FGFR1FGFR4TSHRMAPK1ALDH1A1 | |
| SCHEMBL9738492 | 0.74 | YTHDC1 (0.70) | AXLMERTKFLT3TYRO3 | |
| SCHEMBL9738982 | 0.74 | PDE4A (0.52) | ADORA2AADORA1PDE8AAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110818-A | Antiepileptic agents | CIBA-GEIGY CORPORATION (US) | 1992-05-05 | — | — | US | disclosed |
| EP-0363320-A2 | Substituted 9H purine | CIBA-GEIGY AG (CH) | 1990-04-11 | — | — | EP | disclosed |