Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.32 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13863451 | 0.81 | TDP1 (0.41) | TDP1ALDH1A1LMNAMAPT | |
| SCHEMBL9492702 | 0.79 | TDP1 (0.39) | TDP1FFAR3TP53GRIK1GRIA4 | |
| SCHEMBL17679177 | 0.77 | TDP1 (0.46) | TDP1TP53ADRA1AMAPTCYP1A2 | |
| SCHEMBL16453428 | 0.77 | TDP1 (0.46) | TDP1TP53ADRA1AMAPTCYP1A2 | |
| SCHEMBL25543737 | 0.77 | TDP1 (0.47) | TDP1FFAR3ALDH1A1 | |
| SCHEMBL148545 | 0.77 | TDP1 (0.46) | TDP1TP53ADRA1AMAPTCYP1A2 | |
| SCHEMBL10486524 | 0.76 | MMP1 (0.38) | TP53ALDH1A1RNPEPCYP1A2SLC7A5 | |
| SCHEMBL4527753 | 0.76 | TDP1 (0.36) | TDP1 | |
| SCHEMBL6738773 | 0.75 | TDP1 (0.43) | TDP1TP53ADRA1AMAPTCYP1A2 | |
| SCHEMBL9736766 | 0.75 | TDP1 (0.45) | TDP1FFAR3TP53ACE2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5081145-A | Contractile prostaglandin antagonists | MERCK FROSST CANADA, INC. (CA) | 1992-01-14 | — | — | US | disclosed |
| EP-0166591-A2 | Indole-2-alkanoic acids and their use as prostaglandin antagonists | MERCK FROSST CANADA INC. (CA) | 1986-01-02 | — | — | EP | disclosed |