SCHEMBL9739181

SCHEMBL9739181

Cc1[nH]c2c(Cl)nnc(Cc3ccc(F)cc3)c2c1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
LMNA P02545 2/20 0.37
HPGD P15428 2/20 0.37
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37
PKM P14618 1/20 0.37
SMO Q99835 1/20 0.35
EGFR P00533 1/20 0.34
BTK Q06187 4/20 0.33
NPC1 O15118 1/20 0.32
EGLN1 Q9GZT9 1/20 0.32
PTGS2 P35354 2/20 0.32
PTGS1 P23219 1/20 0.32
BRDT Q58F21 1/20 0.31
NPY5R Q15761 1/20 0.31
CACNA1G O43497 1/20 0.31
CACNA1H O95180 1/20 0.31
CACNA1I Q9P0X4 1/20 0.31
RXFP1 Q9HBX9 1/20 0.30
SIRT5 Q9NXA8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9737888 0.86 SMO (0.40) ALDH1A1HPGDMAPTSMOEGFR
SCHEMBL1828588 0.76 SMO (0.46) ALDH1A1LMNAHPGDGAAMAPT
SCHEMBL9738716 0.75 PARP1 (0.47) ALDH1A1LMNAHPGDGAAMAPT
SCHEMBL9376913 0.73 SMO (0.36) ALDH1A1LMNAHPGDGAAMAPT
SCHEMBL7115917 0.66 SMO (0.44) LMNAHPGDSMOEGFRRXFP1
SCHEMBL3598483 0.66 CYP2C19 (0.41) SMONPC1EGLN1PTGS2PTGS1
SCHEMBL9370750 0.66 OPRM1 (0.40) ALDH1A1LMNAGAANPC1
SCHEMBL23886094 0.65 NPC1 (0.39) ALDH1A1LMNAMAPTSMONPC1
SCHEMBL30020584 0.65 NPC1 (0.39) ALDH1A1LMNAMAPTSMONPC1
SCHEMBL1826754 0.65 SMO (0.48) ALDH1A1LMNASMONPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992006979-A1 NEW DIAZINES BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1992-04-30 WO disclosed