SCHEMBL9737888

SCHEMBL9737888

Cc1[nH]c2c(Cl)nnc(Cc3ccccc3)c2c1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMO Q99835 4/20 0.40
HTR2C P28335 1/20 0.40
EGFR P00533 1/20 0.37
LTB4R Q15722 2/20 0.36
ALDH1A1 P00352 3/20 0.35
MAPT P10636 1/20 0.35
ATM Q13315 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
CCNB2 O95067 1/20 0.34
CCNE2 O96020 1/20 0.34
CDK1 P06493 1/20 0.34
CDK4 P11802 1/20 0.34
CCNB1 P14635 1/20 0.34
CCND1 P24385 1/20 0.34
CCNE1 P24864 1/20 0.34
CDK2 P24941 1/20 0.34
CCNB3 Q8WWL7 1/20 0.34
POLB P06746 1/20 0.33
BRD4 O60885 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9739181 0.86 ALDH1A1 (0.37) SMOEGFRALDH1A1MAPTHPGD
SCHEMBL9376913 0.86 SMO (0.36) SMOHTR2CLTB4RALDH1A1MAPT
SCHEMBL9738731 0.80 CYP19A1 (0.44) ALDH1A1MAPTSMN1; SMN2POLBCYP2C9
SCHEMBL9370750 0.79 OPRM1 (0.40) ALDH1A1NPSR1CCNB2CDK1CCNB1
SCHEMBL1140467 0.75 SMO (0.52) SMOHTR2CALDH1A1MAPTATM
SCHEMBL9371910 0.74 NPSR1 (0.40) SMOHTR2CLTB4RALDH1A1MAPT
SCHEMBL9739821 0.74 ALDH1A1 (0.41) SMOHTR2CEGFRALDH1A1NPSR1
SCHEMBL9747669 0.70 OPRM1 (0.38) SMOHTR2CEGFRLTB4RALDH1A1
SCHEMBL1736684 0.68 CYP1A2 (0.46) HTR2CEGFRLTB4RALDH1A1MAPT
Hydrochloric Acid SCHEMBL1737887 0.67 CYP1A2 (0.45) HTR2CEGFRLTB4RALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992006979-A1 NEW DIAZINES BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1992-04-30 WO disclosed