Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TCF4 | P15884 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8064164 | 0.87 | ALDH1A1 (0.44) | APPMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9739215 | 0.82 | APP (0.41) | APPMAPK1ALDH1A1USP2CYP1A2 | |
| SCHEMBL10350058 | 0.82 | CYP3A4 (0.47) | MAPK1ALDH1A1CYP3A4ALOX15MEN1 | |
| SCHEMBL10888147 | 0.81 | PSMB5 (0.38) | MAPK1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10898487 | 0.80 | PTGS2 (0.32) | — | |
| SCHEMBL10887641 | 0.79 | APP (0.46) | APPMAPK1ALDH1A1TP53HSD17B10 | |
| SCHEMBL6721284 | 0.79 | MAPT (0.50) | APPALDH1A1ALOX15CLK4MEN1 | |
| SCHEMBL7479982 | 0.78 | ALDH1A1 (0.40) | MAPK1ALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL5797082 | 0.77 | MAOB (0.35) | ALDH1A1CYP1A2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL10415428 | 0.76 | AHR (0.42) | USP2CYP3A4CYP2D6MEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134150-A | Administering diaryl-substituted imidazothiazoles; antiarthritic agents | SMITHKLINE BEECHAM CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |
| US-4808607-A | ATHEROSCLEROSIS, HYPERLIPOPROTEINEMIA | SANDOZ PHARM. CORP. (US) | 1989-02-28 | — | — | US | disclosed |