Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 5/20 | 0.40 |
| ▸ | CCND1 | P24385 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212052 | 0.77 | IMPDH2 (0.38) | KDRCYP2A6 | |
| SCHEMBL2391683 | 0.72 | ALDH1A1 (0.52) | METAP2LIMK1CLK4ALDH1A1HSD17B10 | |
| SCHEMBL30174980 | 0.70 | CDK4 (0.60) | METAP2LIMK1CLK4PLK4MAPK9 | |
| SCHEMBL21765723 | 0.70 | CDK4 (0.60) | METAP2LIMK1CLK4PLK4MAPK9 | |
| SCHEMBL2193011 | 0.69 | PIK3CD (0.70) | METAP2LIMK1CLK4PLK4MAPK9 | |
| SCHEMBL29712113 | 0.69 | PIK3CD (0.70) | METAP2LIMK1CLK4PLK4MAPK9 | |
| SCHEMBL442418 | 0.68 | DAO (0.39) | — | |
| SCHEMBL539330 | 0.68 | CYP1A2 (0.46) | ALDH1A1HSD17B10HPGDCYP2A6 | |
| SCHEMBL4276905 | 0.68 | CYP1A2 (0.46) | CYP2A6GAA | |
| SCHEMBL9740801 | 0.68 | MEN1 (0.47) | BCL2L1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |