Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSE | P14091 | 2/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739657 | 1.00 | REN (0.51) | RENMAPK1SMN1; SMN2CTSECTSD | |
| SCHEMBL9741221 | 0.89 | REN (0.45) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9741213 | 0.89 | REN (0.45) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9849721 | 0.76 | REN (0.48) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9741022 | 0.76 | REN (0.55) | REN | |
| SCHEMBL9741017 | 0.76 | REN (0.55) | REN | |
| SCHEMBL9742942 | 0.76 | REN (0.54) | REN | |
| SCHEMBL9742947 | 0.76 | REN (0.54) | REN | |
| SCHEMBL9741102 | 0.72 | MMP2 (0.57) | REN | |
| SCHEMBL9740414 | 0.72 | REN (0.56) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | claimed |