Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 6/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740380 | 0.95 | HCN4 (0.54) | HCN4BRD4MAPTHSP90AA1ALDH1A1 | |
| SCHEMBL9739668 | 0.95 | HCN4 (0.54) | HCN4BRD4MAPTHSP90AA1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10766227 | 0.94 | HCN4 (0.53) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL9738862 | 0.85 | HCN4 (0.44) | HCN4MAPTALDH1A1 | |
| SCHEMBL9212968 | 0.83 | ACHE (0.48) | HCN4BRD4 | |
| Hydrochloric Acid SCHEMBL9739487 | 0.82 | ACHE (0.47) | HCN4BRD4 | |
| SCHEMBL9215863 | 0.81 | BRD4 (0.40) | HCN4BRD4ABCB1 | |
| SCHEMBL9739280 | 0.80 | HCN4 (0.59) | HCN4HTR1ASLC6A4ABCB1MAPT | |
| SCHEMBL10756420 | 0.80 | HCN4 (0.38) | HCN4HTR1ASLC6A4MAPTALDH1A1 | |
| SCHEMBL9740666 | 0.79 | ABCB1 (0.41) | HTR1ASLC6A4ABCB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0224794-B1 | CYCLIC AMINE DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0224794-A2 | Cyclic amine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |